2-Chloro-6-methylisonicotinic acid(CAS: 25462-85-5)

2-Chloro-6-methylisonicotinic acid is a white crystalline solid with a molecular weight of approximately 193.61 g/mol. It has a pKa of about 2.4 and is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. This compound is known for its high reactivity towards nucleophiles and can undergo substitution reactions. It is also prone to hydrolysis under basic conditions.

2-Chloro-6-methylisonicotinic acid can be synthesized via the chlorination of 6-methylnicotinic acid. A common method involves the reaction of 6-methylnicotinic acid with thionyl chloride in the presence of a suitable solvent like dichloromethane. The reaction is typically carried out at room temperature, and the product can be purified by recrystallization from a suitable solvent.

2-Chloro-6-methylisonicotinic acid is primarily used in the pharmaceutical industry as a precursor for the synthesis of various medicinal compounds. It is also relevant in the field of sensor technology for the development of selective gas sensors. Additionally, it has applications in the synthesis of certain polymers and as a reagent in analytical chemistry for its reactivity.

Proper handling of 2-Chloro-6-methylisonicotinic acid requires the use of personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a well-ventilated area away from direct sunlight and incompatible materials. Spills should be handled with care, and the area should be well-ventilated. Emergency eyewash and shower facilities should be available. For detailed safety information, refer to the Material Safety Data Sheet (MSDS/SDS) for this compound.