4-Bromo-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine(CAS: 198545-76-5)

4-Bromo-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine is a white crystalline solid at room temperature. Its molecular weight is approximately 469.32 g/mol. This compound is slightly soluble in water and more soluble in organic solvents like methanol and dichloromethane. It is chemically stable under normal conditions but can react with strong bases and reducing agents. The compound shows low reactivity with common organic reagents.

4-Bromo-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine can be synthesized through multi-step reactions. The synthesis typically involves the installation of a fluorenylmethoxycarbonyl (Fmoc) protecting group on D-phenylalanine, followed by the introduction of a bromine atom. Commonly used reagents include Fmoc-Cl and bromine in a suitable solvent. The reaction is carried out under anhydrous conditions and protected from moisture.

4-Bromo-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine is primarily used in the pharmaceutical industry for the development of novel drugs. It can also find applications in polymer chemistry and as a key intermediate in various organic synthesis processes. Additionally, it may be used in the production of chemical sensors and semiconductors due to its unique chemical properties.

When handling 4-Bromo-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.