3-(4-Chlorobutanoyl)-1H-indole-5-carbonitrile(CAS: 276863-95-7)

3-(4-Chlorobutanoyl)-1H-indole-5-carbonitrile is a solid with a crystalline form. Its molecular weight is approximately 266.03 g/mol. It has low water solubility but is moderately soluble in organic solvents such as dichloromethane and acetonitrile. It is relatively stable under normal conditions but may react with strong bases to form indole derivatives. It is not flammable but should be stored in a cool, dry place away from direct sunlight.

3-(4-Chlorobutanoyl)-1H-indole-5-carbonitrile can be synthesized through a multi-step process involving the condensation of 4-chlorobutanoyl chloride with 1H-indole-5-carbonitrile. This reaction typically proceeds via an acyl substitution reaction. The synthesis involves the use of a Lewis acid catalyst such as aluminum trichloride to enhance the reactivity. The overall yield is moderate, and the method is selective for the desired product.

3-(4-Chlorobutanoyl)-1H-indole-5-carbonitrile is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various indole derivatives. It is also utilized in the chemical industry for its potential applications in polymer synthesis and as a precursor in the development of new materials. Additionally, it may find use in the field of sensor technology and semiconductor manufacturing.

When handling 3-(4-Chlorobutanoyl)-1H-indole-5-carbonitrile, it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up immediately using appropriate absorbent materials. In case of skin contact, wash the area thoroughly with soap and water. Keep the compound away from heat sources and flammable materials. Always consult the safety data sheet (SDS) for detailed information and guidelines.