(4-Acetyl-1-piperazinyl)acetic acid(CAS: 705941-45-3)

(4-Acetyl-1-piperazinyl)acetic acid is a white crystalline solid with a molecular weight of approximately 242.27 g/mol. It is soluble in water and organic solvents. This compound is relatively stable but can react with strong bases to form the corresponding sodium salt. It has a pKa of around 4.5.

(4-Acetyl-1-piperazinyl)acetic acid is commonly synthesized via the condensation of 1-piperazineacetic acid with acetyl chloride in the presence of a catalytic amount of an acid catalyst such as hydrochloric acid. The reaction yields (4-Acetyl-1-piperazinyl)acetic acid in moderate to good yield, with high selectivity for the desired product.

(4-Acetyl-1-piperazinyl)acetic acid is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various piperazine derivatives, which find applications in treating gastrointestinal disorders and other medical conditions. It is also used in the polymer industry for the modification of polymers and in sensor technologies for detecting specific chemical analytes.

When handling (4-Acetyl-1-piperazinyl)acetic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood to avoid inhalation of dust or vapors. Spills should be cleaned up with caution, using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.