2-Chlorobenzamide(CAS: 609-66-5)

2-Chlorobenzamide (CAS: 609-66-5) is a white crystalline solid with a molecular weight of approximately 164.62 g/mol. It is slightly soluble in water and more soluble in organic solvents such as ethanol and acetone. Chemically, it is relatively stable but can undergo hydrolysis in acidic conditions. Its melting point is around 128-130°C.

2-Chlorobenzamide can be synthesized via the acylation of 2-chlorobenzoic acid with an amine, such as aniline, using a coupling agent like dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). The reaction typically requires a base like diisopropylethylamine (DIPEA) and occurs at room temperature or slightly elevated temperatures. The yield is generally high, and the process is relatively straightforward.

2-Chlorobenzamide (CAS: 609-66-5) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for modifying the properties of polymers and in the production of sensors and semiconductors for their specific chemical and physical reactivity.

When handling 2-Chlorobenzamide (CAS: 609-66-5), safety precautions include wearing appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.