N-Acetyl-3,5-diiodo-L-tyrosine(CAS: 1027-28-7)

N-Acetyl-3,5-diiodo-L-tyrosine (CAS: 1027-28-7) is a crystalline solid with a molecular weight of approximately 413.9 g/mol. It is poorly soluble in water and exhibits high reactivity towards iodine radicals. The compound tends to decompose under acidic conditions, making it sensitive to pH changes.

N-Acetyl-3,5-diiodo-L-tyrosine is typically synthesized by the iodination of N-acetyl-L-tyrosine using iodine in an appropriate solvent like acetone or ethyl acetate. The reaction is catalyzed by a phase-transfer catalyst and proceeds with moderate to high selectivity and good yield.

N-Acetyl-3,5-diiodo-L-tyrosine is used in several industries, particularly in pharmaceuticals for its potential as an antithyroid agent. It also finds use in the production of certain sensors and semiconductors due to its unique chemical properties.

When handling N-Acetyl-3,5-diiodo-L-tyrosine, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood. In case of spillage, neutralize the spill with a suitable agent and dispose of any contaminated materials according to safety data sheet (SDS) guidelines.