5-Acetyl-2-thiophenecarbonitrile(CAS: 88653-55-8)

5-Acetyl-2-thiophenecarbonitrile is a solid with a crystalline form, has a molecular weight of approximately 173.23 g/mol, and is slightly soluble in common organic solvents. It is mildly reactive towards nucleophiles and electrophiles, and shows limited reactivity towards bases and acids. Its properties include a melting point of 115-116°C.

5-Acetyl-2-thiophenecarbonitrile can be synthesized by a one-pot reaction of thiophene and acetyl chloride in the presence of a catalyst such as concentrated sulfuric acid. The yield is typically around 85-90%, with selectivity towards the desired product being high.

5-Acetyl-2-thiophenecarbonitrile is used in the pharmaceutical industry for the synthesis of certain drugs, and also in the polymer industry for the production of specific types of plastics and resins. It may also be used in the manufacture of sensors and semiconductors.

When handling 5-Acetyl-2-thiophenecarbonitrile, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up with appropriate absorbent materials. Refer to the Safety Data Sheet (SDS) for detailed safety information.