3-(Benzyloxycarbonylamino)propionaldehyde(CAS: 65564-05-8)

3-(Benzyloxycarbonylamino)propionaldehyde is a colorless or white crystalline solid with a molecular weight of approximately 241.26 g/mol. It has a pKa of about 15.2. The compound is slightly soluble in water but soluble in organic solvents like ethanol and acetone. It is reactive, particularly towards nucleophilic attack at the amino group and the aldehyde group.

3-(Benzyloxycarbonylamino)propionaldehyde is usually synthesized via the condensation of benzyloxycarbonyl chloride with propionic aldehyde. The reaction is catalyzed by Lewis acids like aluminum chloride. The yield is around 70-75%, and the selectivity is high for the desired product.

3-(Benzyloxycarbonylamino)propionaldehyde is used in the pharmaceutical industry as a precursor for the synthesis of various bioactive molecules. It is also employed in the polymer industry for the preparation of functionalized polymers and in the semiconductor industry for the production of photoresists.

When handling 3-(Benzyloxycarbonylamino)propionaldehyde, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be performed in a well-ventilated area or fume hood. Spills should be carefully cleaned up using appropriate absorbents, and disposal should follow local regulations. Always refer to the Material Safety Data Sheet (MSDS/SDS) for specific handling instructions.