3-Aminopyridine-4-thiol(CAS: 89002-13-1)

3-Aminopyridine-4-thiol (CAS: 89002-13-1) is a white crystalline solid with a molecular weight of 167.18 g/mol. It has a melting point of 100-102°C and is slightly soluble in water. It is known for its reactivity towards nucleophiles and can undergo substitution reactions. This compound is typically stored in a desiccator away from moisture.

3-Aminopyridine-4-thiol is commonly synthesized through the reduction of 3-chloropyridine-4-thiol using sodium borohydride as a reducing agent. The process involves mild conditions and yields up to 95% of the desired product, with good selectivity for the thiol group.

3-Aminopyridine-4-thiol is widely used in the pharmaceutical industry for drug synthesis, particularly as a starting material for prodrugs. It also finds applications in the sensor industry for the development of gas sensors and in the polymer industry for modification of polymer properties. Additionally, it is used in semiconductor manufacturing for organic light-emitting diodes (OLEDs).

When handling 3-Aminopyridine-4-thiol (CAS: 89002-13-1), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be immediately neutralized with an appropriate acid or base, followed by thorough cleaning. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.