2-(Trifluoromethyl)phenol(CAS: 444-30-4)

2-(Trifluoromethyl)phenol (CAS: 444-30-4) is a crystalline solid with a molecular weight of approximately 188.14 g/mol. It has a high melting point of around 100-102°C and is slightly soluble in water. Chemically, it is known for its stability but can undergo electrophilic aromatic substitution reactions. It is often used in organic synthesis and has low volatility and low toxicity.

2-(Trifluoromethyl)phenol (CAS: 444-30-4) can be synthesized via electrophilic aromatic substitution of 2-chloro-3,4-difluorobenzene with sodium hydroxide. Commonly, this involves the chlorination of a benzene ring followed by a nucleophilic aromatic substitution reaction. The process typically yields a high purity product with good selectivity and yield.

2-(Trifluoromethyl)phenol (CAS: 444-30-4) is widely used in the pharmaceutical industry for the synthesis of various compounds. It is also utilized in polymer production, where it serves as a stabilizer or monomer. Additionally, it is employed in the development of chemical sensors and in semiconductor manufacturing processes for its unique chemical properties.

When handling 2-(Trifluoromethyl)phenol (CAS: 444-30-4), it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with the aid of absorbent materials and appropriate cleaning agents. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.