3-((1R,3R,4R)-4-Hydroxy-3-methoxycyclohexyl)-2-methylacrylaldehyde, (E)-(CAS: 109466-74-2)

The compound 3-((1R,3R,4R)-4-Hydroxy-3-methoxycyclohexyl)-2-methylacrylaldehyde, (E)- is a colorless or white crystalline solid. Its molecular weight is approximately 238.32 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. It is reactive due to the presence of an aldehyde group and a double bond, making it suitable for various chemical reactions and applications.

This compound can be synthesized through a multistep process involving the preparation of a methoxycyclohexanol, followed by hydroxylation, ring opening, and alkylation steps. Commonly used catalysts include transition metals like palladium. The overall process yields a high purity product with good selectivity. Typical yields range from 60-80%.

This compound is primarily used in pharmaceuticals for the synthesis of active pharmaceutical ingredients (APIs) due to its structural complexity and reactivity. It also finds applications in polymers for modifying properties, sensors for detecting specific compounds, and semiconductors for electronic devices. Its unique chemical structure makes it valuable in these industries.

When handling this compound, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn to protect against skin contact and inhalation. Working in a well-ventilated area or fume hood is essential to avoid exposure. In case of spill, neutralize with an appropriate substance and clean up using personal protective equipment. Always consult the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.