2-Bromo-3-fluoroaniline(CAS: 111721-75-6)

2-Bromo-3-fluoroaniline is a white crystalline solid with a molecular weight of approximately 226.01 g/mol. It is slightly soluble in water and readily soluble in organic solvents like ethanol. Chemically, it is a weak base and demonstrates moderate reactivity towards nucleophiles, making it useful in various chemical reactions. Its physical properties include a melting point of 73-74°C and a boiling point of 242-244°C under reduced pressure.

2-Bromo-3-fluoroaniline is typically synthesized via the bromination of 3-fluoroaniline. This process often involves the use of bromine in the presence of a Lewis acid catalyst such as aluminum bromide. The reaction is carried out in an organic solvent, and the yield is generally good, with high selectivity towards the desired product.

2-Bromo-3-fluoroaniline is used primarily in the pharmaceutical industry, where it serves as a precursor for the synthesis of various medicinal compounds. It also finds applications in the polymer industry for the production of certain functional polymers. Additionally, it is utilized in the development of sensors and semiconductors due to its unique electronic properties.

When handling 2-Bromo-3-fluoroaniline, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials and the cleanup area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.