3-Bromo-4-methylbenzoic acid(CAS: 7697-26-9)

3-Bromo-4-methylbenzoic acid is a white to off-white crystalline solid with a molecular weight of approximately 228.04 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. Chemically, it is reactive towards bases and nucleophiles, making it useful in various synthetic transformations.

3-Bromo-4-methylbenzoic acid is commonly synthesized via bromination of 4-methylbenzoic acid using N-bromosuccinimide (NBS) in the presence of a radical initiator like AIBN. The reaction is typically carried out in an inert solvent like acetonitrile, yielding a high purity product with good selectivity and yield.

3-Bromo-4-methylbenzoic acid is used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also employed in the polymer industry for the development of functionalized polymers and in the semiconductor industry for certain photoresist materials.

When handling 3-Bromo-4-methylbenzoic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work in a fume hood to minimize inhalation risks. Store in a cool, dry place away from heat sources. In case of spill, use appropriate spill kits and follow safety data sheet (SDS) guidelines for disposal.