(4,6-Dichloro-5-pyrimidinyl)acetaldehyde(CAS: 16019-33-3)

(4,6-Dichloro-5-pyrimidinyl)acetaldehyde is a white crystalline solid with a molecular weight of approximately 232.03 g/mol. It has a slight solubility in water and is more soluble in organic solvents like ethanol and acetonitrile. Chemically, it is moderately reactive, particularly towards nucleophiles and reducing agents.

(4,6-Dichloro-5-pyrimidinyl)acetaldehyde can be synthesized by the alkylation of 5-chloropyrimidine with acetaldehyde in the presence of a base like potassium hydroxide. The reaction is carried out in an aprotic solvent like acetonitrile at room temperature. The yield is typically around 75% with good selectivity.

(4,6-Dichloro-5-pyrimidinyl)acetaldehyde is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various pyrimidine-based drugs. It also finds applications in the polymer industry for the development of novel materials and in sensor technology for detecting specific chemical species.

When handling (4,6-Dichloro-5-pyrimidinyl)acetaldehyde, use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.