1,3-Difluoro-5-methylbenzene(CAS: 117358-51-7)

1,3-Difluoro-5-methylbenzene is a colorless liquid with a molecular weight of approximately 133.12 g/mol. It has a boiling point of 172.5°C and a melting point of -31°C. The compound is slightly soluble in water but soluble in organic solvents. It is chemically stable but can undergo electrophilic aromatic substitution reactions under certain conditions.

1,3-Difluoro-5-methylbenzene can be synthesized through the reaction of 5-methylbenzaldehyde with hydrogen fluoride to form 5-fluoro-1-methylbenzene, followed by the reaction with hydrogen fluoride to introduce the second fluorine atom. Alternatively, it can be obtained by the reaction of methylbenzene with hydrogen fluoride in the presence of a Lewis acid catalyst.

1,3-Difluoro-5-methylbenzene is used in the pharmaceutical industry for the synthesis of various drug intermediates, in polymer production as a monomer, in the manufacturing of sensors, and as a precursor in semiconductor industry processes.

When handling 1,3-Difluoro-5-methylbenzene, proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbents, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.