(S)-2-((1S,3R,4S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride(CAS: 135729-76-9)

(S)-2-((1S,3R,4S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride is a crystalline white solid. It has a molecular weight of approximately 420.7 g/mol. The compound is soluble in organic solvents like ethanol and acetone. Chemically, it is less reactive towards common nucleophiles but can undergo various transformations under specific conditions. It is sparingly soluble in water.

(S)-2-((1S,3R,4S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride is synthesized via a multi-step process. The key step involves the condensation of (S)-quinuclidin-3-yl alcohol with 1H-benzo[de]isoquinolin-1-one followed by hydrochloride formation. Common catalysts include phosphorus oxychloride, and the overall yield is typically around 70-80%.

(S)-2-((1S,3R,4S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride is primarily used in the pharmaceutical industry for its potential as a chiral intermediate in drug synthesis. It may also find applications in the formulation of certain sensors and as a building block in the synthesis of complex organic molecules.

Proper personal protective equipment (PPE) should be worn when handling (S)-2-((1S,3R,4S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride (CAS: 135729-76-9). This includes gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area, such as a fume hood. Spills should be contained and cleaned up with appropriate absorbents. A Material Safety Data Sheet (MSDS) should be consulted for detailed safety information.