2,4-Dichloro-5-iodopyrimidine(CAS: 13544-44-0)

2,4-Dichloro-5-iodopyrimidine is a crystalline compound with a molecular weight of approximately 319.04 g/mol. It has a low solubility in water but is more soluble in organic solvents like acetonitrile and dimethylformamide. Chemically, it is relatively stable but can undergo nucleophilic substitution reactions. It is a solid at room temperature and is typically stored in a dry, dark place to prevent photodegradation.

2,4-Dichloro-5-iodopyrimidine is typically synthesized through a substitution reaction where an iodine atom is introduced into the pyrimidine ring. The synthesis involves the reaction of 2,4-dichloropyrimidine with iodine in the presence of a Lewis acid catalyst, such as iron(III) chloride. The yield and selectivity of the reaction depend on the reaction conditions, including temperature and solvent choice.

2,4-Dichloro-5-iodopyrimidine is used in the pharmaceutical industry for the synthesis of specific drug intermediates. It also finds applications in the semiconductor industry for the production of certain photolithography resists and in the field of sensors for its unique chemical reactivity.

When handling 2,4-Dichloro-5-iodopyrimidine, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be cleaned up immediately using appropriate absorbent materials. In case of accidental ingestion or skin contact, seek medical attention and refer to the Safety Data Sheet (SDS) for further guidance.