3-Fluoro-4-methoxybenzaldehyde(CAS: 351-54-2)

3-Fluoro-4-methoxybenzaldehyde is a crystalline compound with a molecular weight of approximately 194.12 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. Chemically, it is less reactive compared to similar aromatic aldehydes but can undergo typical aldehyde reactions such as nucleophilic addition. The compound exhibits a melting point of 74-76°C and a boiling point of 209-210°C.

3-Fluoro-4-methoxybenzaldehyde is typically synthesized through the reduction of 3-fluoro-4-methoxybenzoyl chloride using sodium borohydride or a similar reducing agent under anhydrous conditions. The reaction involves the addition of the reducing agent to the chlorinated substrate, followed by work-up to isolate the aldehyde product. This method provides good yield and selectivity.

3-Fluoro-4-methoxybenzaldehyde is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drug molecules. It also finds applications in the production of organic semiconductors and as a reagent in analytical chemistry for the preparation of sensors and detection methods.

When handling 3-Fluoro-4-methoxybenzaldehyde, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be stored in a well-ventilated area and preferably in a fume hood to minimize exposure. In case of a spill, avoid inhalation and contact with skin or eyes. Refer to the safety data sheet (SDS) for detailed emergency procedures and storage guidelines.