[2-Chloro-4-(methoxycarbonyl)phenyl]boronic acid(CAS: 603122-80-1)

[2-Chloro-4-(methoxycarbonyl)phenyl]boronic acid is a crystalline solid with a molecular weight of approximately 252.02 g/mol. It has a low water solubility, and its solubility in organic solvents is moderate. The compound is moderately reactive, particularly towards nucleophiles. It is stable under normal laboratory conditions but should be stored in a dry environment to prevent hydrolysis.

[2-Chloro-4-(methoxycarbonyl)phenyl]boronic acid is commonly synthesized via a Grignard reaction followed by a boronation step. The Grignard reagent is prepared from chlorophenol with magnesium, and the boronic acid is generated by treating the Grignard reagent with triphenylborane in the presence of a base. This method provides good yield and selectivity.

[2-Chloro-4-(methoxycarbonyl)phenyl]boronic acid finds applications in pharmaceuticals for drug synthesis, particularly in the area of asymmetric synthesis. It is also used in the synthesis of polymers, sensors, and semiconductors due to its reactivity and functional groups.

When handling [2-Chloro-4-(methoxycarbonyl)phenyl]boronic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Ensure to work in a well-ventilated area or fume hood to avoid inhalation of dust. Spills should be cleaned up using appropriate absorbents, and disposal should follow local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information.