4-Bromo-3-fluorophenol(CAS: 121219-03-2)

4-Bromo-3-fluorophenol (CAS: 121219-03-2) is a white crystalline solid with a molecular weight of approximately 219.03 g/mol. It has a pKa of about 9.35 and is slightly soluble in water (solubility around 0.1 g/L at 25°C). The compound is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored away from moisture and heat sources.

4-Bromo-3-fluorophenol (CAS: 121219-03-2) can be synthesized via the bromination of 3-fluorophenol using bromine in the presence of a Lewis acid catalyst such as aluminum bromide. The reaction is typically carried out in a non-aqueous solvent like dichloromethane. The yield is usually around 70-80%, and the method is selective for the bromination of the phenolic hydroxyl group.

4-Bromo-3-fluorophenol (CAS: 121219-03-2) is used in various industries. It serves as a precursor in the pharmaceutical industry for the synthesis of certain drugs. In the polymer industry, it can be utilized as a monomer or additive. Additionally, it finds applications in the development of sensors and as a reagent in analytical chemistry. The compound's unique chemical properties make it valuable in these sectors.

When handling 4-Bromo-3-fluorophenol (CAS: 121219-03-2), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to avoid inhalation of the vapor. Spills should be contained and cleaned up using appropriate procedures. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions. The compound can irritate the skin and eyes, and prolonged exposure may cause health issues.