2-Chloro-4-hydroxybenzoic acid(CAS: 56363-84-9)

2-Chloro-4-hydroxybenzoic acid is a crystalline solid with a molecular weight of approximately 186.59 g/mol. It has a high solubility in water (20 g/100 mL at 25°C) and is slightly soluble in ethanol and acetone. Chemically, it exhibits typical acidic properties due to the carboxylic acid group, and the presence of chlorine and hydroxyl groups makes it reactive in various organic synthesis reactions.

2-Chloro-4-hydroxybenzoic acid is typically synthesized by the chlorination of 4-hydroxybenzoic acid. The reaction is performed under basic conditions using chlorine gas. The process involves careful control of the reaction temperature and time to ensure high selectivity and yield. Common solvents used include benzene or toluene to facilitate the reaction.

2-Chloro-4-hydroxybenzoic acid finds applications in the pharmaceutical industry, where it can be used as an intermediate in the synthesis of certain drugs. It is also used in the chemical industry as a reagent for various organic transformations. Additionally, it has applications in the polymer industry for modifying polymer properties and in the development of sensors and semiconductors.

When handling 2-Chloro-4-hydroxybenzoic acid, it is important to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a well-ventilated area and handled in a fume hood to minimize exposure to vapors. Spills should be cleaned up using appropriate safety measures, and the material safety data sheet (MSDS) should always be consulted for specific handling and disposal guidelines.