(3,4-Difluorophenyl)boronic acid(CAS: 168267-41-2)

(3,4-Difluorophenyl)boronic acid is a colorless solid with a crystalline form. Its molecular weight is approximately 204.07 g/mol. It is slightly soluble in water but more soluble in organic solvents. Chemically, it is an acid and can undergo reactions such as esterification and nucleophilic substitution.

(3,4-Difluorophenyl)boronic acid can be synthesized via the Suzuki coupling reaction using 3,4-difluorophenyl boronic pinacol ester and a palladium catalyst. The reaction typically yields the desired product with good selectivity and moderate to high efficiency.

(3,4-Difluorophenyl)boronic acid finds applications in pharmaceuticals, where it is used in the synthesis of drug intermediates, and in polymer science, where it serves as a monomer or cross-linking agent. It is also utilized in the development of sensors and semiconductors.

When handling (3,4-Difluorophenyl)boronic acid, it is important to use appropriatePersonal Protective Equipment (PPE) such as gloves, goggles, and lab coats. Work should be done in a well-ventilated area or within a fume hood. Spills should be cleaned up immediately using appropriate safety measures. Always consult the Safety Data Sheet (SDS) for specific handling instructions.