5-Chlorobenzotriazole(CAS: 94-97-3)

5-Chlorobenzotriazole (CAS: 94-97-3) is a white crystalline solid with a molecular weight of 191.58 g/mol. It has a slight yellow color and a melting point of 152-155°C. Solubility in water is low, but it is soluble in most organic solvents. It is highly reactive, particularly in the presence of bases and is used in the synthesis of peptides and organic compounds.

5-Chlorobenzotriazole (CAS: 94-97-3) is synthesized by chlorination of benzotriazole using thionyl chloride. The reaction is carried out under anhydrous conditions to increase yield and purity. Solvent choice, temperature, and catalysts such as imidazole are critical for optimal results. The process yields a high-purity product with good selectivity.

5-Chlorobenzotriazole (CAS: 94-97-3) is primarily used in the pharmaceutical industry for the synthesis of peptide drugs. It is also utilized in the polymer industry for the preparation of special polymers and in the semiconductor industry for the production of photolithography resists. In addition, it has applications in sensors and as a protective reagent in organic synthesis.

When handling 5-Chlorobenzotriazole (CAS: 94-97-3), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Always work in a well-ventilated area or fume hood to avoid inhalation. Avoid skin contact and ingestion. In case of spill, use appropriate spill kits and dispose of waste materials according to local regulations. Consult the Safety Data Sheet (SDS) for further safety information.