Basimglurant(CAS: 8023-93-6)

Basimglurant (CAS: 8023-93-6) is a white to off-white crystalline solid with a molecular weight of approximately 444.48 g/mol. It has a low solubility in water but is soluble in organic solvents like DMSO and ethanol. Basimglurant is relatively stable under normal conditions but may react with strong oxidizing agents. It has a pKa of about 11.5.

Basimglurant (CAS: 8023-93-6) can be synthesized via a multi-step process involving the condensation of 4-bromobenzaldehyde and 2-aminothiazole followed by amination and amidation steps. The synthesis typically requires the use of catalysts such as triphenylphosphine and an appropriate amine source. The overall yield is around 70% with good selectivity.

Basimglurant (CAS: 8023-93-6) is primarily used in the pharmaceutical industry as an investigational drug for treating cognitive impairment associated with Alzheimer’s disease. It is also explored for its potential as a neuroprotective agent in neurodegenerative disorders.

When handling Basimglurant (CAS: 8023-93-6), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area, preferably within a fume hood. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Users should consult the Safety Data Sheet (SDS) for detailed safety information.