27-Hydroxycholesterol(CAS: 20380-11-4)

27-Hydroxycholesterol (CAS: 20380-11-4) is a naturally occurring metabolite of cholesterol. It is a white to slightly off-white crystalline solid with a molecular weight of approximately 368.46 g/mol. It has limited water solubility and is soluble in organic solvents such as methanol and chloroform. It is relatively stable under normal conditions but can undergo oxidation under acidic or basic conditions.

27-Hydroxycholesterol (CAS: 20380-11-4) can be synthesized through several routes, with the most common involving the oxidation of cholesta-5,7,24-trien-3β-ol using hydrogen peroxide or peracids in the presence of catalytic amounts of a suitable oxidizing agent such as manganese(IV) oxide. The reaction is selective and provides good yield, with the product typically purified by column chromatography.

27-Hydroxycholesterol (CAS: 20380-11-4) is of interest in the pharmaceutical industry for its potential therapeutic applications, particularly in the treatment of cardiovascular diseases and neurodegenerative disorders. It is also used in sensor technology and as a precursor in the synthesis of other cholesterol derivatives.

When handling 27-Hydroxycholesterol (CAS: 20380-11-4), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work should be carried out in a well-ventilated area or fume hood due to its potential for oxidation. Spills should be cleaned up with appropriate absorbents and the area should be flushed with water. Always consult the Material Safety Data Sheet (MSDS) for specific safety information and guidelines.