Tert-butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate(CAS: 918644-73-2)

Tert-butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate is a white crystalline solid with a molecular weight of approximately 273.38 g/mol. It is slightly soluble in water and more soluble in organic solvents. The compound is reactive towards nucleophiles and can undergo ester hydrolysis under basic conditions. It is stable under normal conditions but should be stored away from moisture and heat.

Tert-butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate can be synthesized via a multi-step process involving the protection of a carboxylic acid with tert-butyl chloride, followed by the introduction of the azaspiro structure via a ring-closing reaction. The synthesis involves the use of catalytic amounts of a Lewis acid and proceeds with good regioselectivity and yield.

Tert-butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate finds applications in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also used in the polymer industry for the modification of polymer properties and in the sensor industry for its potential use in detection systems.

When handling Tert-butyl 9-hydroxy-3-azaspiro[5.5]undecane-3-carboxylate, it is important to use appropriate personal protective equipment (PPE), including gloves and safety goggles. It should be stored in a cool, dry place away from direct sunlight. In case of spills, they should be handled carefully using appropriate procedures and materials, and a Material Safety Data Sheet (MSDS) should be consulted for detailed instructions.