Methyl 2-methyl-5-nitrobenzoate(CAS: 77324-87-9)

Methyl 2-methyl-5-nitrobenzoate is a crystalline solid with a molecular weight of approximately 226.16 g/mol. It has a melting point of 66-68°C and a boiling point of 308-310°C. The compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It is a reactive compound, particularly towards nucleophiles in substitution reactions.

Methyl 2-methyl-5-nitrobenzoate is typically synthesized via nitration of 2-methylbenzoic acid. The process involves the reaction of 2-methylbenzoic acid with nitric acid (HNO3) in the presence of sulfuric acid (H2SO4) as a catalyst. The nitration yields the desired product with good selectivity and moderate to high yield depending on the reaction conditions.

Methyl 2-methyl-5-nitrobenzoate finds application in the pharmaceutical industry as an intermediate for the synthesis of certain drugs. It is also used in the production of dyes and pigments, and as a component in some polymer formulations. Additionally, it is utilized in the development of organic sensors and semiconductors.

When handling Methyl 2-methyl-5-nitrobenzoate, it is important to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled by neutralizing the compound with a suitable reagent before cleanup. Always refer to the Safety Data Sheet (SDS) for detailed safety guidelines and emergency procedures.