4-Bromo-3,5-difluorophenol(CAS: 130191-91-2)

4-Bromo-3,5-difluorophenol is a white to off-white crystalline solid with a molecular weight of approximately 246.01 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is less reactive compared to its brominated counterparts but can undergo typical electrophilic aromatic substitution reactions. Its physical properties include a melting point of 68-69°C and a boiling point of around 250°C.

4-Bromo-3,5-difluorophenol is typically synthesized by bromination of 3,5-difluorophenol. The reaction usually involves the use of N-bromosuccinimide (NBS) as the brominating agent in the presence of a radical initiator such as benzoyl peroxide. The yield can be up to 75% with high selectivity, and the reaction is conducted at room temperature to avoid side reactions.

4-Bromo-3,5-difluorophenol is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the production of sensors and in the development of materials for semiconductors. Due to its chemical properties, it is used in the manufacture of various organic compounds and as an intermediate in polymer chemistry.

When handling 4-Bromo-3,5-difluorophenol, it is essential to use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to avoid inhalation of the vapor. Spills should be immediately cleaned up using appropriate absorbent materials. For detailed safety information, refer to the Material Safety Data Sheet (MSDS) for 4-Bromo-3,5-difluorophenol (CAS: 130191-91-2).