4-Bromo-2-methylbenzonitrile(CAS: 67832-11-5)

4-Bromo-2-methylbenzonitrile is a colorless to light yellow liquid. It has a molecular weight of approximately 203.04 g/mol and a boiling point of around 215°C. The compound is slightly soluble in water but soluble in common organic solvents like ethanol and acetone. It is moderately reactive, showing some electrophilic aromatic substitution reactivity.

4-Bromo-2-methylbenzonitrile is commonly synthesized via the bromination of 2-methylbenzonitrile. This process involves the use of bromine in the presence of a Lewis acid catalyst such as aluminum bromide. The reaction is carried out in a solvent like dichloromethane, with high selectivity and good yield typically achieved under mild conditions.

4-Bromo-2-methylbenzonitrile is primarily used in the pharmaceutical industry for the synthesis of various chemical intermediates and drugs. It is also employed in the polymer industry for the production of specialty polymers and in the electronics sector for the development of sensors and semiconductors.

When handling 4-Bromo-2-methylbenzonitrile, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be carried out in a fume hood to minimize exposure. Spills should be cleaned up carefully, using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed spill response procedures.