5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile(CAS: 741709-63-7)

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile is a crystalline compound with a molecular weight of approximately 320.3 g/mol. It has limited water solubility and is soluble in common organic solvents like DMSO and DMF. This compound exhibits moderate reactivity, particularly in Borylation reactions. It is stable under normal conditions but should be stored in a dry environment to prevent moisture absorption.

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile is typically synthesized via a Borylation reaction. The process involves the coupling of 2-pyridinecarbonitrile with 1,3,2-dioxaborinane in the presence of a palladium catalyst, such as Pd(PPh3)2Cl2, and a base like sodium carbonate. This synthesis yields a high purity product with good selectivity and yield.

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various pharmaceutical compounds and is also utilized in the development of new polymers due to its unique chemical properties.

When handling 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile, it is essential to use appropriate personal protective equipment (PPE) such as gloves and goggles. It should be stored in a closed container in a dry, well-ventilated area. In case of spill, handle with care and dispose of in accordance with local regulations. For detailed safety information, refer to the Safety Data Sheet (SDS).