4-Bromo-3-methylphenol(CAS: 14472-14-1)

4-Bromo-3-methylphenol (CAS: 14472-14-1) is a white crystalline solid with a molecular weight of approximately 189.03 g/mol. It has a pKa of about 8.2. The compound is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. It is moderately reactive towards nucleophiles and can undergo substitution reactions. It is a weak acid and exhibits weak basic properties under certain conditions.

4-Bromo-3-methylphenol (CAS: 14472-14-1) is typically synthesized via the bromination of 3-methylphenol using N-bromosuccinimide (NBS) as a brominating agent under UV light. The reaction is conducted in a chloroform or acetone solvent at room temperature. The yield is around 75-80%, and the product is usually purified by recrystallization from hot ethanol.

4-Bromo-3-methylphenol (CAS: 14472-14-1) finds applications in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also used in the polymer industry for the production of certain types of polyphenols. Additionally, it is employed in the development of sensors and semiconductor materials due to its redox properties and aromatic structure.

When handling 4-Bromo-3-methylphenol (CAS: 14472-14-1), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be performed in a well-ventilated area or fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.