1-aminopyrrole-2-carboxamide(CAS: 159326-69-9)

1-Aminopyrrole-2-carboxamide (CAS: 159326-69-9) is a white crystalline solid with a molecular weight of approximately 148.15 g/mol. It is sparingly soluble in water and has a pKa of about 6.5. The compound is moderately reactive, particularly with bases and nucleophiles. It is stable under normal storage conditions but should be protected from moisture and air to prevent degradation.

1-Aminopyrrole-2-carboxamide can be synthesized via amide coupling of 1-cyanopyrrole-2-carboxylic acid with ammonia or an amine. Commonly, this is achieved using coupling reagents like HATU or EDC with a base such as DIPEA. The reaction yields 90-95% pure product with good selectivity and moderate to good yield.

1-Aminopyrrole-2-carboxamide (CAS: 159326-69-9) is primarily used in pharmaceutical and chemical research for its functional amide group and basic nitrogen. It finds applications in the development of new drugs, polymers, and as a precursor in organic synthesis. Additionally, it is used in the production of sensors and semiconductors due to its chemical properties.

When handling 1-aminopyrrole-2-carboxamide (CAS: 159326-69-9), it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coat. The compound should be handled in a well-ventilated area or fume hood to avoid inhalation or skin contact. Spills should be cleaned up with caution, using appropriate absorbent materials. Always consult the Material Safety Data Sheet (MSDS/SDS) for detailed safety instructions and emergency procedures.