2-Methylsuccinic acid(CAS: 498-21-5)

2-Methylsuccinic acid is a colorless crystalline solid with a molecular weight of approximately 136.13 g/mol. It has a pKa of around 4.9 and is moderately soluble in water. This compound is reactive and can undergo esterification and condensation reactions. It is also readily soluble in common organic solvents like ethanol and acetone.

2-Methylsuccinic acid can be synthesized through the hydration of 2-methylmaleic anhydride or by the condensation of succinic anhydride with 2-hydroxypropane-1,3-diol. Common catalysts include sulfuric acid and phosphoric acid. The yield is typically around 85-95%, and the reaction is performed under mild conditions to ensure high selectivity.

2-Methylsuccinic acid finds applications in the pharmaceutical industry for the synthesis of various drugs, in the polymer industry for improving the properties of plastics, and in the sensor industry for the development of gas sensors. It is also used in the semiconductor industry as a precursor for the manufacture of organic semiconductors.

When handling 2-Methylsuccinic acid, appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat should be worn. It should be stored in a cool, dry place away from heat sources and incompatible substances. In case of a spill, it should be handled in a fume hood, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.