trans-Doxercalciferol(CAS: 74007-20-8)

Trans-Doxercalciferol is a white-to-off-white crystalline solid with a molecular weight of approximately 426.6 g/mol. It has a high melting point and low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is stable under normal conditions but requires protection from light and moisture to prevent degradation.

Trans-Doxercalciferol is synthesized through a multistep process involving the hydroxylation of 7-dehydrocholesterol. The initial step involves exposure to ultraviolet light to initiate the conversion, followed by chemical modifications to achieve the trans isomer. This process often requires the use of catalysts like copper compounds to enhance selectivity and yield.

Trans-Doxercalciferol is primarily used in the pharmaceutical industry for its vitamin D3 activity. It is also utilized in the food industry as a dietary supplement and fortifier. Additionally, it has potential applications in the cosmetic industry for skin health and in the agricultural sector as a feed additive for livestock.

When handling trans-Doxercalciferol, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and protective goggles. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the affected area should be flushed with water. Safety data sheets (SDS) should be consulted for detailed information on handling and storage conditions.