5-Bromo-4-methylpyridine-2-carbonitrile(CAS: 886364-86-9)

5-Bromo-4-methylpyridine-2-carbonitrile (CAS: 886364-86-9) is a crystalline solid with a molecular weight of approximately 217.05 g/mol. It has low solubility in water but is soluble in organic solvents like methanol and acetonitrile. Chemically, it is reactive with bases and can undergo nucleophilic substitution reactions. It is also prone to hydrolysis under basic conditions.

5-Bromo-4-methylpyridine-2-carbonitrile is typically synthesized via a nucleophilic substitution reaction. The process involves reacting 4-methylpyridine-2-carbonitrile with bromine in the presence of a Lewis acid catalyst, such as aluminum bromide. The reaction is carried out in an inert solvent, and the yield is generally high, around 80-90%.

5-Bromo-4-methylpyridine-2-carbonitrile (CAS: 886364-86-9) is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various drugs and also finds applications as a monomer in the production of certain polymers.

When handling 5-Bromo-4-methylpyridine-2-carbonitrile (CAS: 886364-86-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to avoid inhalation. In case of a spill, immediately clean up using appropriate absorbents and follow proper disposal procedures. Always refer to the Safety Data Sheet (SDS) for detailed safety information.