4-(1-Piperazinyl)aniline(CAS: 67455-41-8)

4-(1-Piperazinyl)aniline (CAS: 67455-41-8) is a crystalline solid with a molecular weight of approximately 217.26 g/mol. It is slightly soluble in water and ethanol. The compound is reactive towards basic conditions and can undergo electrophilic aromatic substitution reactions. It has a pKa of about 8.5, indicating basicity.

4-(1-Piperazinyl)aniline is typically synthesized by the Suzuki coupling of 1-piperazinecarboxylic acid phenyl ester with phenylboronic acid in the presence of a palladium catalyst and a base such as sodium carbonate. The reaction yields a high purity product with good selectivity and high yield.

4-(1-Piperazinyl)aniline (CAS: 67455-41-8) is used in the pharmaceutical industry for the synthesis of various drugs, particularly those requiring basic functional groups. It is also utilized in the polymer industry for the preparation of functional polymers and in the electronics industry for the production of semiconductors and sensors.

When handling 4-(1-Piperazinyl)aniline, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate safety protocols, and the Material Safety Data Sheet (MSDS/SDS) should be consulted for detailed information on handling and storage.