2,6,6-Trimethyl-1-cyclohexene-1-carbaldehyde(CAS: 432-25-7)

2,6,6-Trimethyl-1-cyclohexene-1-carbaldehyde is a colorless liquid with a molecular weight of 142.22 g/mol. It has a high boiling point of around 195°C and a low solubility in water. It is relatively stable but can react with strong nucleophiles. This compound is prone to undergo acyl migration and can form intramolecular hemiacetals.

2,6,6-Trimethyl-1-cyclohexene-1-carbaldehyde is typically synthesized via a Wittig reaction where methyl iodide is treated with a 2,6,6-trimethylcyclohexanone in the presence of a phosphonium salt, such as ethyltriphenylphosphonium bromide, as a catalyst. The yield is generally around 80-85%, and the method is selective and efficient.

2,6,6-Trimethyl-1-cyclohexene-1-carbaldehyde is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in the production of polymers, where it can serve as a monomer, and in the manufacturing of sensors for detecting specific chemical compounds. Additionally, it is used in the semiconductor industry as a precursor for organic thin-film transistors.

When handling 2,6,6-Trimethyl-1-cyclohexene-1-carbaldehyde, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and lab coats. It should be stored in a well-ventilated area, preferably in a fume hood, to prevent inhalation. In case of a spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety instructions.