1-(4-Chlorophenyl)acetone(CAS: 5586-88-9)

1-(4-Chlorophenyl)acetone (CAS: 5586-88-9) is a colorless crystalline solid with a molecular weight of 186.64 g/mol. It has a pKa of 12.0 and is poorly soluble in water but soluble in organic solvents like ethanol and acetone. It is moderately reactive, capable of undergoing nucleophilic substitution at the chloro group and condensation reactions.

1-(4-Chlorophenyl)acetone is typically synthesized from 4-chlorophenylacetaldehyde by acetoxylation using acetic anhydride and a catalytic amount of sulfuric acid. The reaction yields a high purity product with good selectivity and a reasonable yield of 75-85%.

1-(4-Chlorophenyl)acetone (CAS: 5586-88-9) is used in the pharmaceutical industry for the production of certain chiral compounds and intermediates. It is also used in the production of sensors and semiconductors due to its specific chemical properties.

When handling 1-(4-Chlorophenyl)acetone (CAS: 5586-88-9), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. It should be stored in a sealed, dry container away from strong oxidizers and reduce agents. In case of spill, use appropriate spill kits and dispose of waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for additional information and guidelines.