Methyl (2S)-3-bromo-2-methylpropanoate(CAS: 98190-85-3)

Methyl (2S)-3-bromo-2-methylpropanoate is a colorless liquid with a molecular weight of approximately 184.03 g/mol. It has a melting point of -36°C and a boiling point of 132-134°C. The compound is slightly soluble in water but miscible with many organic solvents. It is a reactive compound due to the presence of a bromine atom, making it prone to nucleophilic substitution reactions.

Methyl (2S)-3-bromo-2-methylpropanoate is typically synthesized via a bromination reaction of 2-methyl-3-methylpropanol with bromine in the presence of a base such as potassium hydroxide. The reaction is carried out in an aprotic solvent like acetone. The yield is generally good, with selectivity towards the (2S) configuration.

Methyl (2S)-3-bromo-2-methylpropanoate is used in various industries, including pharmaceuticals for the synthesis of certain drugs, and in the production of polymers for their specific mechanical properties. It is also used in the development of sensors and as a building block in semiconductor manufacturing.

When handling Methyl (2S)-3-bromo-2-methylpropanoate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and lab coat. Work should be done in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents. Refer to the Safety Data Sheet (SDS) for detailed emergency response procedures and storage conditions.