Ethyl 1-(3-chlorophenyl)-5-cyano-1H-pyrazole-4-carboxylate(CAS: 98476-16-5)

Ethyl 1-(3-chlorophenyl)-5-cyano-1H-pyrazole-4-carboxylate is a crystalline solid with a molecular weight of approximately 291.04 g/mol. It has poor water solubility but good solubility in organic solvents such as ethanol and acetone. This compound is highly reactive, showing potential for nucleophilic substitution reactions. It is also susceptible to acid and base hydrolysis.

Ethyl 1-(3-chlorophenyl)-5-cyano-1H-pyrazole-4-carboxylate is commonly synthesized via a multistep process involving the formation of cyano-phenyl intermediate followed by its condensation with 1-ethoxy-5-pyrazole-4-carboxylic acid. The reaction typically requires a strong base such as sodium hydride and is conducted in a suitable solvent like dimethylformamide (DMF).

Ethyl 1-(3-chlorophenyl)-5-cyano-1H-pyrazole-4-carboxylate is utilized in the pharmaceutical industry for the development of new drugs, particularly in the synthesis of antiviral and anti-inflammatory agents. It is also explored in the development of materials for electronic and optoelectronic applications due to its unique electronic properties.

When handling Ethyl 1-(3-chlorophenyl)-5-cyano-1H-pyrazole-4-carboxylate, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize exposure. In case of spill, dispose of the material according to the safety data sheet (SDS) guidelines. Always refer to the latest SDS for detailed safety information.