Quasi-homogeneous catalytic conversion of CO2 into quinazolinones inside a metal–organic framework microreactor
Literature Information
Zhenzhen Zhou, Jian-Gong Ma, Jianbo Gao
Management of CO2 has been attracting great attention in this century. Reaction of CO2 with 2-haloanilines and isocyanides is an attractive way for both converting CO2 and producing quinazolinones, which are key intermediates for the synthesis of various biologically active products. However, the heterogeneous and relatively inert nature of CO2 with 2-haloaniline and isocyanide reactants limits the types of suitable catalysts. Herein, we use metal–organic frameworks (MOFs) as a “microreactor”, in which Pd(PPh3)2Cl2 is well-dispersed as a single-molecular catalyst, and the reactants react in the molecular level through a “quasi-homogeneous” way to convert CO2 into quinazolinones under mild conditions with both promising yields over homogeneous catalysts and good recyclability as a heterogeneous reaction. The MOF-assisted single-molecular catalysis strategy should contribute to CO2 conversion, production of quinazolinone-type bioactive intermediates, and the epochal development of “homo-and-heterogeneous” catalysis.
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Green Chemistry

Green Chemistry provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on, but not limited to, the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998). Green chemistry is the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry is at the frontiers of this continuously-evolving interdisciplinary science and publishes research that attempts to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. Submissions on all aspects of research relating to the endeavour are welcome. The journal publishes original and significant cutting-edge research that is likely to be of wide general appeal. To be published, work must present a significant advance in green chemistry. Papers must contain a comparison with existing methods and demonstrate advantages over those methods before publication can be considered. For more information please see this Editorial. Coverage includes the following, but is not limited to: Design (e.g. biomimicry, design for degradation/recycling/reduced toxicity…) Reagents & Feedstocks (e.g. renewables, CO2, solvents, auxiliary agents, waste utilization…) Synthesis (e.g. organic, inorganic, synthetic biology…) Catalysis (e.g. homogeneous, heterogeneous, enzyme, whole cell…) Process (e.g. process design, intensification, separations, recycling, efficiency…) Energy (e.g. renewable energy, fuels, photovoltaics, fuel cells, energy storage, energy carriers…) Applications (e.g. electronics, dyes, consumer products, coatings, pharmaceuticals, preservatives, building materials, chemicals for industry/agriculture/mining…) Impact (e.g. safety, metrics, LCA, sustainability, (eco)toxicology…) Green chemistry is, by definition, a continuously-evolving frontier. Therefore, the inclusion of a particular material or technology does not, of itself, guarantee that a paper is suitable for the journal. To be suitable, the novel advance should have the potential for reduced environmental impact relative to the state of the art. Green Chemistry does not normally deal with research associated with 'end-of-pipe' or remediation issues.











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