Covalent capture of supramolecular species in an aqueous solution of water-miscible small organic molecules

Literature Information

Publication Date 2019-04-23
DOI 10.1039/C9CP01427F
Impact Factor 3.676
Authors

Yongchao Yao, Chuanqi Li, Fangqin Liu, Pengxiang Zhao


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Abstract

Since an early report in the 1970s, the mesoscale inhomogeneities formed in an aqueous solution of water-miscible small organic molecules have been debated for over forty years with a variety of explanations. Although it was recently established that these inhomogeneities are supramolecular species caused by trace impurities, the structure of the supramolecular species and the mechanism behind their formation are not yet clear. By means of covalent capture, we herein disclose that the formation mechanism of the supramolecular species consists of a two-step self-assembly process: the small molecules first assemble into primary micelles with a trace amount of impurity, and the formed dynamic ultra-small micelles aggregate further through hydrogen bonding to achieve a buildup of thermodynamic mesoscale inhomogeneities. Based on this finding, supramolecular species have been used as elements for pH-responsive size-changeable drug carriers, which respond to the acidic tumour extracellular milieu and decompose into small particles for deep tumour penetration and effective distribution.

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Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

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