Analysis of transition state stabilization by non-covalent interactions in organocatalysis: application of atomic and functional-group partitioned symmetry-adapted perturbation theory to the addition of organoboron reagents to fluoroketones

Literature Information

Publication Date 2018-06-20
DOI 10.1039/C8CP02029A
Impact Factor 3.676
Authors

Brandon W. Bakr


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Abstract

This work seeks to apply symmetry-adapted perturbation theory (SAPT) to the recent study of Hoveyda and co-workers [K. A. Lee et al., Nat. Chem. 2016, 8, 768] where an allyl addition to a ketone became enantioselective when the ketone was fluorinated. Through the application of atomic SAPT (A-SAPT) and functional-group SAPT (F-SAPT), the non-covalent interactions between specific atoms and functional groups in the transition states associated with the fluoroketone reactions can be quantified. Our A-SAPT analysis confirms that a H⋯F contact thought to enhance stereoselectivity shows a strong preference for one of the transition states leading to the experimentally observed product enantiomer. Other key atom–atom contacts invoked to rationalize relative transition state energies are also found to behave as expected based on chemical intuition and contact distances. On the other hand, hypothesized steric clashes between substrate phenyl or ortho-methyl phenyl groups and the catalyst are not supported by F-SAPT computations, and indeed, these are actually favorable π–π interactions.

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Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
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Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

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