Ru(ii)-Catalyzed spirocyclization of aryl N-sulfonyl ketimines with aryl isocyanates through an aromatic C–H bond activation

Literature Information

Publication Date 2018-03-13
DOI 10.1039/C7OB03198J
Impact Factor 3.876
Authors

Subhadra U., Sridhar B., Subba Reddy B. V.


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Abstract

A novel one-pot strategy has been developed for the construction of spiro-isoindolinone-benzosultams through a Ru(II)-catalyzed sequential C–C and C–N bond formation. This method is highly atom-economical and compatible with a wide range of substituents. This is the first report on the spirocyclization of 3-aryl N-sulfonyl ketimines with aryl isocyanates to produce highly rigid and pharmaceutically relevant spirocycles through a C–H bond activation.

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Organic & Biomolecular Chemistry
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