Pyrazole synthesis via a cascade Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones

Literature Information

Publication Date 2017-11-29
DOI 10.1039/C7OB02576A
Impact Factor 3.876
Authors

Ying Yang, Zi-Lin Hu, Ren-Hao Li, Yi-Hui Chen, Zhuang-Ping Zhan


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Abstract

An efficient approach for the preparation of pyrazoles via a Pd(II)/Cu(I)-catalyzed Sonogashira coupling/cyclization of N-propargyl sulfonylhydrazones has been established. In this study, we firstly report the strategic use of a Sonogashira reaction to construct pyrazole rings in a one step operation. With a broad range of functional group tolerance, bioactive 3-CF3 pyrazoles can also be synthesized easily through this domino coupling/cyclization sequence.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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