S-Nitrosothiol-modified hyperbranched polyesters
Literature Information
Publication Date
2016-11-02
DOI
10.1039/C6PY01516F
Impact Factor
5.582
Authors
Lei Yang, Yuan Lu, Robert J. Soto, Anand Shah, Mona Jasmine R. Ahonen, Mark H. Schoenfisch
View Original
Abstract
Hyperbranched polyesters with a range of exterior thiol modifications were synthesized through a Michael addition thiol–ene reaction. S-Nitrosothiol nitric oxide (NO) donors were subsequently introduced onto the scaffolds to yield NO-releasing polyesters with total NO storage of ∼2.0 µmol mg−1. Multiple decomposition pathways (i.e., use of light, copper ions, and heat) triggered S-nitrosothiol NO donor breakdown and NO release under physiological conditions (37 °C, pH 7.4). The NO-releasing polyesters were characterized as a function of chemical modification and scaffold size or generation. The approaches described herein expand the scope of biodegradable NO-releasing materials with large NO payloads.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
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