Enzymatic conversion of magnetic nanoparticles to a non-magnetic precipitate: a new approach to magnetic sensing
Literature Information
Publication Date
2016-07-25
DOI
10.1039/C6AN00709K
Impact Factor
4.616
Authors
Arati G. Kolhatkar, Andrew C. Jamison, Ivan Nekrashevich, Katerina Kourentzi, Audrius Brazdeikis, T. Randall Lee
View Original
Abstract
Magnetic sensing utilizes the detection of biomolecule-conjugated magnetic nanoparticles (MNPs). Our new strategy offers a novel approach to magnetic sensing where in situ conversion produces a “loss of signal” in the sensing device. This report demonstrates the enzymatic conversion of Fe3O4 MNPs to a non-magnetic precipitate via reduction by L-ascorbic acid generated by the action of alkaline phosphatase.
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