Non-ionic water-soluble “clickable” α-helical polypeptides: synthesis, characterization and side chain modification
Literature Information
Publication Date
2014-12-18
DOI
10.1039/C4PY01560F
Impact Factor
5.582
Authors
Jinbao Cao, Ping Hu, Lu Lu, Brandon A. Chan, Bing-Hao Luo, Donghui Zhang
View Original
Abstract
A series of water-soluble non-ionic “clickable” polypeptides has been synthesized by organo-initiated ring-opening co-polymerization (ROP) of γ-propargyl-L-glutamic acid N-carboxyanhydride (PLG NCA) and N-ε-2-[2-(2-methoxyethoxy)ethoxy]acetyl-L-lysine N-carboxyanhydride (EG2-LYS NCA). The pendant alkyne side groups can be modified with azido-containing hydrophobic and hydrophilic bioactive moieties, producing polypeptide conjugates with good water solubility. Circular dichroism (CD) reveals that both the parent polypeptides and the modified polypeptide conjugates maintain high levels of α-helical conformations in aqueous solutions. A preliminary cell study indicated the cell binding peptide GRGDS (Gly-Arg-Gly-Asp-Ser) modified copolymers are able to induce integrin-mediated cell adhesion.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
6-amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS Number:
6642-31-5
Molecular Formula:
C6H9N3O2
![1,1',1'',1'''-[Disulfanediylbis(carbonothioylnitrilo)]tetraethane structure](https://static.chemtradehub.com/structs/97-/97-77-8-f3e4.webp "1,1',1'',1'''-[Disulfanediylbis(carbonothioylnitrilo)]tetraethane structure")
1,1',1'',1'''-[Disulfanediylbis(carbonothioylnitrilo)]tetraethane
CAS Number:
97-77-8
Molecular Formula:
C10H20N2S4
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