Resonance Raman detection of the myoglobin nitrito heme Fe–O–NO/2-nitrovinyl species: implications for helix E-helix F interactions

Literature Information

Publication Date 2014-12-18
DOI 10.1039/C4CP04352A
Impact Factor 3.676
Authors

Alexandra Lambrou, Eftychia Pinakoulaki


View Original

Abstract

The description of biological activity in heme proteins responsible for activating small molecules requires identification of ligand movement into the metal and non-metal binding sites. Mechanisms of nitrite reductase activity in globins are difficult to verify without the structures of the bound ligand, but we now have such information from resonance Raman spectroscopy on the myoglobin nitrito heme Fe–O–NO/2-nitrovinyl species in their natural environment rather than in crystals. Our results indicate that the formation of the nitrito heme Fe–O–NO/2-nitrovinyl species is pH-dependent. The conditions under which the nitrito heme Fe–O–NO/2-nitrovinyl species is generated strongly suggest that this form corresponds to an acid induced transformation. We propose that the movement of helices E and F at low pH results in the protonation of nitrito heme Fe–O–NO by His64 Nε–H(E) to form the nitrous heme Fe–O(H)–NO species.

Related Literature

An energetic evaluation of dissolution corrosion capabilities of liquid metals on iron surface

Yichun Xu, Chi Song, Yange Zhang, C. S. Liu, B. C. Pan, Zhiguang Wang

2014-06-18 Paper

DOI: 10.1039/C4CP01224K

Back matter

Front/Back Matter

DOI: 10.1039/C4CP90106A

Chirped-pulse millimeter-wave spectroscopy for dynamics and kinetics studies of pyrolysis reactions

G. Barratt Park, Rachel G. Shaver, AnGayle K. Vasiliou, James M. Oldham, Donald E. David, John S. Muenter, John F. Stanton, Arthur G. Suits, G. Barney Ellison, Robert W. Field

2014-03-31 Perspective

DOI: 10.1039/C3CP55352C

Ab initio molecular dynamics simulations of aqueous triflic acid confined in carbon nanotubes

Jeffrey K. Clark II, Bradley F. Habenicht, Stephen J. Paddison

2014-06-20 Paper

DOI: 10.1039/C4CP01066C

Aggregation induced emission enhancement from Bathophenanthroline microstructures and its potential use as sensor of mercury ions in water

Prativa Mazumdar, Debasish Das, Gobinda Prasad Sahoo, Guillermo Salgado-Morán, Ajay Misra

2014-01-13 Paper

DOI: 10.1039/C3CP54563F

Excited-state properties of fluorenones: influence of substituents, solvent and macrocyclic encapsulation

Indrajit Ghosh, Arindam Mukhopadhyay, Apurba Lal Koner, Subhas Samanta, Werner M. Nau, Jarugu Narasimha Moorthy

2014-06-13 Paper

DOI: 10.1039/C4CP01724B

Two pulse-coupled non-identical, frequency-different BZ oscillators with time delay

Anastasia I. Lavrova, Vladimir K. Vanag

2014-01-14 Paper

DOI: 10.1039/C3CP54373K

Back cover

Cover

DOI: 10.1039/C4CP90107J

You might also like

Compound Q&A

What are the main uses of (5-Sulfamoyl-3-pyridinyl)boronic acid (CAS: 951233-61-7)?

(5-Sulfamoyl-3-pyridinyl)boronic acid is primarily used in chemical synthesis, p...

951233-61-7(5-Sulfamoyl-3-pyrid...
Compound Q&A

How is Benzyl 2-methyl-2-(methylsulfonyl)-4-pentenoate (CAS: 1942858-50-5) typically synthesized?

Benzyl 2-methyl-2-(methylsulfonyl)-4-pentenoate is typically synthesized via est...

1942858-50-5Benzyl 2-methyl-2-(m...
Compound Q&A

What precautions should be taken when handling 8-Fluoroquinolin-6-ol (CAS: 209353-22-0)?

When handling 8-Fluoroquinolin-6-ol (CAS: 209353-22-0), it is important to use p...

209353-22-08-Fluoroquinolin-6-o...
Compound Q&A

What are the physical and chemical properties of 1,3-Dibromo-5-(2-methyl-2-propanyl)benzene (CAS: 129316-09-2)?

1,3-Dibromo-5-(2-methyl-2-propanyl)benzene (CAS: 129316-09-2) is a crystalline c...

129316-09-21,3-Dibromo-5-(2-met...
Compound Q&A

What industries use Ethyl 7-chloro-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylate (CAS: 174726-87-5)?

Ethyl 7-chloro-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carbox...

174726-87-5Ethyl 7-chloro-4-oxo...
Compound Q&A

What precautions should be taken when handling Delta-7-Avenasterol (CAS: 23290-26-8)?

When handling Delta-7-Avenasterol (CAS: 23290-26-8), it is important to wear app...

23290-26-8Delta-7-Avenasterol
872992-20-6N-({(5R)-3-[3-Fluoro...
Compound Q&A

What precautions should be taken when handling 2-Methyl-2-proanyl 4-[(2-aminophenyl)amino]-1-piperidinecarboxylate (CAS: 79099-00-6)?

When handling 2-Methyl-2-proanyl 4-[(2-aminophenyl)amino]-1-piperidinecarboxylat...

79099-00-62-Methyl-2-propanyl ...
Compound Q&A

What is N-Methyl-4-chlorobenzylamine hydrochloride (CAS: 65542-24-7)?

N-Methyl-4-chlorobenzylamine hydrochloride (CAS: 65542-24-7) is a organic compou...

65542-24-7N-Methyl-4-chloroben...
Compound Q&A

Is [2-(Dodecyloxy)ethoxy]acetic acid (CAS: 27306-90-7) safe?

[2-(Dodecyloxy)ethoxy]acetic acid (CAS: 27306-90-7) is generally considered safe...

27306-90-7[2-(Dodecyloxy)ethox...

Source Journal

Physical Chemistry Chemical Physics

Physical Chemistry Chemical Physics
CiteScore: 5.5
Self-citation Rate: 10.3%
Articles per Year: 3036

Physical Chemistry Chemical Physics (PCCP) is an international journal co-owned by 19 physical chemistry and physics societies from around the world. This journal publishes original, cutting-edge research in physical chemistry, chemical physics and biophysical chemistry. To be suitable for publication in PCCP, articles must include significant innovation and/or insight into physical chemistry; this is the most important criterion that reviewers and Editors will judge against when evaluating submissions. The journal has a broad scope and welcomes contributions spanning experiment, theory, computation and data science. Topical coverage includes spectroscopy, dynamics, kinetics, statistical mechanics, thermodynamics, electrochemistry, catalysis, surface science, quantum mechanics, quantum computing and machine learning. Interdisciplinary research areas such as polymers and soft matter, materials, nanoscience, energy, surfaces/interfaces, and biophysical chemistry are welcomed if they demonstrate significant innovation and/or insight into physical chemistry. Joined experimental/theoretical studies are particularly appreciated when complementary and based on up-to-date approaches.

Recommended Compounds

Recommended Suppliers

Disclaimer
This page provides academic journal information for reference and research purposes only. We are not affiliated with any journal publishers and do not handle publication submissions. For publication-related inquiries, please contact the respective journal publishers directly.
If you notice any inaccuracies in the information displayed, please contact us at support@chemtradehub.com. We will promptly review and address your concerns.