![4-Chloro-2-{[(2-chlorophenoxy)acetyl]amino}benzoic acid structure](https://static.chemtradehub.com/structs/351/351424-20-9-9467.webp "4-Chloro-2-{[(2-chlorophenoxy)acetyl]amino}benzoic acid structure")
4-Chloro-2-{[(2-chlorophenoxy)acetyl]amino}benzoic acid
CAS Number:
351424-20-9
Molecular Formula:
C15H11Cl2NO4
Online multi-channel microfluidic chip-mass spectrometry and its application for quantifying noncovalent protein–protein interactions
Literature Information
Publication Date
2015-01-06
DOI
10.1039/C4AN02370F
Impact Factor
4.616
Authors
Wu Liu, Qiushui Chen, Xuexia Lin, Jin-Ming Lin
View Original
Abstract
To establish an automatic and online microfluidic chip-mass spectrometry (chip-MS) system, a device was designed and fabricated for microsampling by a hybrid capillary. The movement of the capillary was programmed by a computer to aspirate samples from different microfluidic channels in the form of microdroplets (typically tens of nanoliters in volume), which were separated by air plugs. The droplets were then directly analyzed by MS via paper spray ionization without any pretreatment. The feasibility and performance were demonstrated by a concentration gradient experiment. Furthermore, after eliminating the effect of nonuniform response factors by an internal standard method, determination of the association constant within a noncovalent protein–protein complex was successfully accomplished with the MS-based titration indicating the versatility and the potential of this novel platform for widespread applications.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
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2-(7,7-Difluorobicyclo[4.1.0]hept-1-yl)ethanamine
CAS Number:
2098065-08-6
Molecular Formula:
C9H15F2N
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